{
    "$schema": "https://bigdickpills.com/data/schema/aua-ed-guideline-evidence.schema.json",
    "name": "AUA Erectile Dysfunction Guideline Dataset: All 25 Statements, With Strength and Evidence Grade",
    "license": "CC BY 4.0 — attribute Big Dick Pills and link to https://bigdickpills.com/data/aua-ed-guideline-evidence/",
    "source": "https://www.auanet.org/guidelines-and-quality/guidelines/erectile-dysfunction-(ed)-guideline",
    "checked": "2026-09-24",
    "records": 25,
    "statements": [
        {
            "treatment_or_action": "Oral PDE5 inhibitors",
            "detail": "sildenafil, tadalafil, vardenafil, avanafil",
            "guideline_summary": "Should be discussed with every man with ED, unless contraindicated",
            "recommendation_strength": "Strong",
            "evidence_grade": "B"
        },
        {
            "treatment_or_action": "PDE5i dose titration",
            "detail": "",
            "guideline_summary": "Dose should be titrated for optimal effect",
            "recommendation_strength": "Strong",
            "evidence_grade": "B"
        },
        {
            "treatment_or_action": "PDE5i usage instructions",
            "detail": "",
            "guideline_summary": "Instructions should be given to maximise benefit",
            "recommendation_strength": "Strong",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Penile prosthesis",
            "detail": "",
            "guideline_summary": "Should be discussed as a treatment option",
            "recommendation_strength": "Strong",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Vacuum erection device",
            "detail": "",
            "guideline_summary": "Should be discussed as a treatment option",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Intracavernosal injections",
            "detail": "",
            "guideline_summary": "Should be discussed as a treatment option",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Morning total testosterone",
            "detail": "",
            "guideline_summary": "Should be measured in men with ED",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Lifestyle change",
            "detail": "diet, physical activity",
            "guideline_summary": "Improves overall health and may improve erectile function",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "PDE5i plus testosterone",
            "detail": "",
            "guideline_summary": "May be more effective together in men with testosterone deficiency",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Mental health referral",
            "detail": "",
            "guideline_summary": "Should be considered to aid adherence and reduce anxiety",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Early PDE5i after prostate cancer treatment",
            "detail": "",
            "guideline_summary": "Men should be told it may not improve spontaneous function",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Penile venous surgery",
            "detail": "",
            "guideline_summary": "Not recommended",
            "recommendation_strength": "Moderate",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Intraurethral alprostadil",
            "detail": "",
            "guideline_summary": "Should be discussed as a treatment option",
            "recommendation_strength": "Conditional",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Penile arterial reconstruction",
            "detail": "",
            "guideline_summary": "May be considered in selected young men with focal arterial blockage",
            "recommendation_strength": "Conditional",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Low-intensity shockwave therapy",
            "detail": "LI-ESWT, acoustic wave, GAINSWave",
            "guideline_summary": "Should be considered investigational",
            "recommendation_strength": "Conditional",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Intracavernosal stem cell therapy",
            "detail": "",
            "guideline_summary": "Should be considered investigational",
            "recommendation_strength": "Conditional",
            "evidence_grade": "C"
        },
        {
            "treatment_or_action": "Platelet-rich plasma",
            "detail": "PRP, the “P-Shot”",
            "guideline_summary": "Should be considered experimental",
            "recommendation_strength": "Expert Opinion",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "History, examination, selective labs",
            "detail": "",
            "guideline_summary": "Should be done in every man presenting with ED",
            "recommendation_strength": "Clinical Principle",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "ED as a cardiovascular warning",
            "detail": "",
            "guideline_summary": "Men should be counselled that ED is a risk marker for heart disease",
            "recommendation_strength": "Clinical Principle",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "In-office test before intraurethral alprostadil",
            "detail": "",
            "guideline_summary": "Should be performed",
            "recommendation_strength": "Clinical Principle",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "In-office test before injections",
            "detail": "",
            "guideline_summary": "Should be performed",
            "recommendation_strength": "Clinical Principle",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "Counselling before prosthesis surgery",
            "detail": "",
            "guideline_summary": "Post-operative expectations should be discussed",
            "recommendation_strength": "Clinical Principle",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "Prosthesis surgery during infection",
            "detail": "",
            "guideline_summary": "Should not be performed",
            "recommendation_strength": "Clinical Principle",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "Validated questionnaires",
            "detail": "",
            "guideline_summary": "Recommended to assess severity and track treatment",
            "recommendation_strength": "Expert Opinion",
            "evidence_grade": "None (ungraded)"
        },
        {
            "treatment_or_action": "Specialised testing",
            "detail": "",
            "guideline_summary": "May be necessary in some men to guide treatment",
            "recommendation_strength": "Expert Opinion",
            "evidence_grade": "None (ungraded)"
        }
    ],
    "url": "https://bigdickpills.com/data/aua-ed-guideline-evidence/",
    "json_url": "https://bigdickpills.com/data/aua-ed-guideline-evidence.json",
    "generated": "2026-09-25T23:25:13+00:00",
    "publisher": {
        "name": "Big Dick Pills",
        "url": "https://bigdickpills.com/"
    },
    "disclaimer": "Informational dataset published by Big Dick Pills (bigdickpills.com), an independent research site. Not medical advice; see a licensed clinician for treatment decisions."
}