{
    "$schema": "https://bigdickpills.com/data/schema/pde5-inhibitors-compared.schema.json",
    "name": "PDE5 Inhibitors Compared Dataset: Sildenafil, Tadalafil, Vardenafil and Avanafil by Dose, Onset and Half-Life",
    "license": "CC BY 4.0 — attribute Big Dick Pills and link to https://bigdickpills.com/data/pde5-inhibitors-compared/",
    "source": "https://bigdickpills.com/erectile-dysfunction/which-pde5-inhibitor-to-choose/",
    "checked": "2026-09-24",
    "head_to_head": "Tadalafil vs sildenafil: 0.03 points on a 30-point scale (95% CI -0.32 to 0.39), 16 trials, 5,189 men (Chen L et al., 2017)",
    "records": 4,
    "drugs": [
        {
            "drug": "Sildenafil (Viagra)",
            "usual_doses": "25 to 100 mg",
            "onset": "30 to 60 min",
            "half_life": "2.6 to 3.7 h",
            "useful_window": "Up to 12 h"
        },
        {
            "drug": "Tadalafil (Cialis)",
            "usual_doses": "5 to 20 mg on demand; 2.5 to 5 mg daily",
            "onset": "About 30 min, peak near 2 h",
            "half_life": "17.5 h",
            "useful_window": "Up to 36 h"
        },
        {
            "drug": "Vardenafil (Levitra)",
            "usual_doses": "5 to 20 mg",
            "onset": "About 30 min",
            "half_life": "3.9 h",
            "useful_window": "Similar to sildenafil"
        },
        {
            "drug": "Avanafil (Stendra)",
            "usual_doses": "50 to 200 mg",
            "onset": "15 to 30 min",
            "half_life": "6 to 17 h",
            "useful_window": "Shorter than tadalafil"
        }
    ],
    "url": "https://bigdickpills.com/data/pde5-inhibitors-compared/",
    "json_url": "https://bigdickpills.com/data/pde5-inhibitors-compared.json",
    "generated": "2026-09-25T23:24:49+00:00",
    "publisher": {
        "name": "Big Dick Pills",
        "url": "https://bigdickpills.com/"
    },
    "disclaimer": "Informational dataset published by Big Dick Pills (bigdickpills.com), an independent research site. Not medical advice; see a licensed clinician for treatment decisions."
}