treatment_or_action,detail,guideline_summary,recommendation_strength,evidence_grade Oral PDE5 inhibitors,"sildenafil, tadalafil, vardenafil, avanafil","Should be discussed with every man with ED, unless contraindicated",Strong,B PDE5i dose titration,,Dose should be titrated for optimal effect,Strong,B PDE5i usage instructions,,Instructions should be given to maximise benefit,Strong,C Penile prosthesis,,Should be discussed as a treatment option,Strong,C Vacuum erection device,,Should be discussed as a treatment option,Moderate,C Intracavernosal injections,,Should be discussed as a treatment option,Moderate,C Morning total testosterone,,Should be measured in men with ED,Moderate,C Lifestyle change,"diet, physical activity",Improves overall health and may improve erectile function,Moderate,C PDE5i plus testosterone,,May be more effective together in men with testosterone deficiency,Moderate,C Mental health referral,,Should be considered to aid adherence and reduce anxiety,Moderate,C Early PDE5i after prostate cancer treatment,,Men should be told it may not improve spontaneous function,Moderate,C Penile venous surgery,,Not recommended,Moderate,C Intraurethral alprostadil,,Should be discussed as a treatment option,Conditional,C Penile arterial reconstruction,,May be considered in selected young men with focal arterial blockage,Conditional,C Low-intensity shockwave therapy,"LI-ESWT, acoustic wave, GAINSWave",Should be considered investigational,Conditional,C Intracavernosal stem cell therapy,,Should be considered investigational,Conditional,C Platelet-rich plasma,"PRP, the “P-Shot”",Should be considered experimental,Expert Opinion,None (ungraded) "History, examination, selective labs",,Should be done in every man presenting with ED,Clinical Principle,None (ungraded) ED as a cardiovascular warning,,Men should be counselled that ED is a risk marker for heart disease,Clinical Principle,None (ungraded) In-office test before intraurethral alprostadil,,Should be performed,Clinical Principle,None (ungraded) In-office test before injections,,Should be performed,Clinical Principle,None (ungraded) Counselling before prosthesis surgery,,Post-operative expectations should be discussed,Clinical Principle,None (ungraded) Prosthesis surgery during infection,,Should not be performed,Clinical Principle,None (ungraded) Validated questionnaires,,Recommended to assess severity and track treatment,Expert Opinion,None (ungraded) Specialised testing,,May be necessary in some men to guide treatment,Expert Opinion,None (ungraded)