Will Preston
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PSA Screening: The Numbers Behind a Decision Nobody Will Make For You
Per 1,000 men screened: 1.3 prostate cancer deaths prevented, 100 diagnosed, about 50 left with sexual dysfunction. Why the recommendation is a conversation, and how to have it.
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Alcohol and Men’s Health: What the 2025 Reviews Actually Found
Two federal reviews landed weeks apart and seemed to contradict each other, and then the dietary guidelines dropped their numeric limits. What the evidence says about alcohol, cancer, testosterone, erections and sleep.
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Sleep Apnea in Men: The Condition Behind the Snoring
Around 80% of moderate-to-severe sleep apnea is never diagnosed. What it does to blood pressure, mood and erections, how to screen yourself in eight questions, and what treatment actually delivers.
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The Health Checks Worth Having, by Age
The annual physical, as a package, does not lower death rates. A short list of specific screens does. Here is that list, by age, with the evidence grade for each.
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Vitamin D: What the Biggest Trial Actually Found
25,871 people, 2,000 IU a day, five years. No reduction in cancer. No reduction in major cardiovascular events. And screening healthy adults is graded “we do not know.”
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Does Testosterone Fix Low Mood and Low Energy?
The trial designed specifically to test vitality found testosterone did not improve fatigue or low energy. The one thing it clearly improved was libido: the opposite of the pitch.
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GLP-1s and Alcohol: The Craving Signal, and What the Trials Actually Show
People on GLP-1s kept reporting they had lost interest in drinking. Two randomised trials have now tested it. The effect is real, the evidence is early, and the drug is not approved for this.
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Pornography and Erectile Function: What the Evidence Actually Supports
No causal link has been demonstrated. What correlates is self-perceived problematic use, about 2 to 8% of users, not frequency. And the arrow may point the other way.
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Who Actually Qualifies for a GLP-1?
The BMI thresholds are specific, the contraindications are absolute, and the indications have expanded well beyond weight. What the label actually says, and the questions you should be asked before a prescription.
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How Depression Actually Presents in Men
The male suicide rate is nearly four times the female rate, and highest in men over 75. Yet men are diagnosed with depression less often. The presentation is a large part of why.
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Strength Training and How Long You Live: The Dose Is Smaller Than You Think
A meta-analysis found any resistance training cut all-cause mortality 15%, with the maximum benefit at about 60 minutes a week. More was not better. Combined with cardio, the reduction reached 40%.
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Antidepressants and Sexual Side Effects: The Numbers Nobody Quotes
Asked systematically, 84.5% of men on antidepressants report sexual dysfunction. Left to volunteer it, 42.5% do. Three management strategies have randomised evidence.
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Tirzepatide vs Semaglutide: What the Head-to-Head Trial Found
751 adults, 72 weeks, randomised directly against each other. Tirzepatide produced 20.2% weight loss against semaglutide’s 13.7%, and men lost about 6% less than women on both.
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GLP-1 Side Effects: The Real Rates, and Which Ones Actually Matter
Nausea affects 44% of people on semaglutide, not the handful the advertising implies. Here are the label rates, which effects are merely unpleasant, and the two that mean stop and call someone.
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Compounded Semaglutide: What You Are Actually Buying
The shortage ended and the legal basis for compounding copies expired in 2025. The FDA has logged 990 adverse event reports for compounded semaglutide, and says they are underreported.
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Colorectal Screening Starts at 45 Now, Not 50
The start age moved in 2021 because incidence in adults aged 40 to 49 rose almost 15%. There are six approved ways to screen, and the best one is the one you will actually…
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Blood Pressure: The Highest-Value Number in Men’s Health
It is the only Grade A screen that applies to every adult from 18, it causes no symptoms until it causes a stroke, and the trial that tested treating it harder was stopped early…
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Do GLP-1s Cost You Muscle? What the Body Composition Data Show
A quarter to a third of the weight lost is lean tissue, proportionate to any large weight loss, not selective muscle wasting. But 5.6 kg is still 5.6 kg, and it does not come…
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Hair Transplants: What to Understand Before You Book
A transplant moves hair. It does not create it, and it does not stop the loss continuing around it, which is why the men with the worst results are usually the ones who stopped…
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The Shedding Phase: Why Hair Treatment Makes Things Worse First
Men start minoxidil, shed heavily around month two or three, conclude it is destroying their hair, and quit, right before it starts working. Here is what is actually happening.