All articles
Everything published so far, newest first. Every clinical claim links to the guideline, review or trial it came from.
Every article here is sourced. The two references used most often are the US Preventive Services Task Force and the Cochrane Library.
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When the Pills Do Not Work: Injections, Vacuum Devices and Implants
Around a third of men do not respond to PDE5 inhibitors, but most of them were taking the drug wrong. For those who genuinely fail, injections, vacuum devices and implants all have real numbers…
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Erectile Dysfunction Is a Cardiovascular Symptom, and It Arrives First
The arteries that fail first are the smallest ones. In men with confirmed coronary disease, two thirds developed erectile dysfunction first, a mean of 38.8 months before any cardiac symptom.
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Semen Analysis: What Each Number on the Report Actually Means
The WHO reference limits are not a line between healthy and unhealthy. They are the fifth percentile of men who conceived naturally within a year, which changes how every number on the report should…
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Exercise for Depression: What 218 Trials Found, and What They Did Not
A BMJ network meta-analysis ranked walking, yoga, strength training and antidepressants against each other across 218 trials. Here are the effect sizes, what worked better in men, and why the authors rated their own…
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Do Penis Enlargement Pills Work? No, and Two Thirds Contain Prescription Drugs
No supplement has ever been shown to change penis size, and no mechanism exists by which one could. When researchers tested 102 products off the shelf, 67 percent contained undeclared prescription ED drugs.
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Doxy-PEP: It Works, and the CDC Does Not Recommend It for Most Men
A single 200 mg doxycycline dose within 72 hours of sex cut chlamydia and syphilis by 70 to 90 percent in randomised trials. Here is what the evidence shows, who the CDC recommends it…
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Oral Minoxidil for Hair Loss: As Good as the Foam, With Different Problems
The only head-to-head trial in men found oral minoxidil 5 mg roughly equivalent to 5% topical over 24 weeks. Unwanted hair growth elsewhere ran at 49% against 25%. It is off-label everywhere, and a…
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Testosterone Replacement: The Warning the FDA Removed, and the One It Added
TRAVERSE found no increase in heart attacks or strokes, and small real increases in atrial fibrillation, kidney injury and pulmonary embolism. In February 2025 the FDA dropped the cardiovascular boxed warning and added one…
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Shockwave Therapy for ED: A Real Effect, Just Below What You Would Notice
Twenty-one randomised trials found a 3.89-point improvement in erectile function. The smallest change men actually notice is about 4 points. Nine of the trials were funded by the device makers, and the average course…
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Viagra, Cialis and the Rest: You Are Choosing a Duration, Not a Strength
Sixteen randomised trials in 5,189 men found no difference in how well tadalafil and sildenafil work. What separates the four PDE5 inhibitors is half-life, food, and which side effect you would rather have.